Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876576 | Applied Radiation and Isotopes | 2011 | 7 Pages |
Abstract
Annexin V imaging is suggested to provide a good indication of cancer treatment efficacy. To study the accuracy of 99mTc-AnxV imaging, we monitored chemo-sensitive and chemo-resistant tumors in a mouse breast cancer model after treatment with docetaxel. Sensitive tumors showed a slight peak in 99mTc-AnxV uptake one day post-treatment, while uptake in resistant tumors remained constant. In contrast to immunohistochemical analysis, 99mTc-AnxV imaging could not be used to predict tumor response, due to large variation between animals.
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Authors
Chantal A.C. Beekman, Tessa Buckle, Anne C. van Leeuwen, Renato A. Valdés Olmos, Marcel Verheij, Sven Rottenberg, Fijs W.B. van Leeuwen,