Automated production of [11C]acetate and [11C]palmitate using a modified GE Tracerlab FXC-Pro

As researchers explore new applications for positron emission tomography radiopharmaceuticals, the demand for effective and readily available radiopharmaceuticals continues to increase. The syntheses of two such radiopharmaceuticals, [11C]acetate and [11C]palmitate, can be automated on the GE Tracerlab FXC-Pro by utilizing Grignard reactions. Radiochemical purities of the [11C]acetate and the [11C]palmitate products were high (>98% and >99.9%, respectively) with average non-corrected yields of 18% (n=3) and 10% (n=5), respectively. These data comprise the validation trials for site qualification of clinical production of both radiopharmaceuticals.

Graphical abstractAutomated syntheses of [11C]acetate and [11C]palmitate using a modified GE Tracerlab FXC-Pro are reported. Radiochemical purities of the [11C]acetate and the [11C]palmitate products were high (>98% and >99.9%, respectively) with average non-corrected yields of 18% (n=3) and 10% (n=5), respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide