Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876607 | Applied Radiation and Isotopes | 2010 | 4 Pages |
Abstract
In the present study, the N-benzyl dithiocarbamate (BZDTC) was synthesized and radiolabeled with [99mTcN]2+ intermediate to form the bis(N-benzyl dithiocarbamato) nitrido technetium-99m complex [99mTcN(BZDTC)2]. The radiochemical purity of the complex was over 90% by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). It was stable over 6Â h at room temperature. The partition coefficient and electrophoresis results indicated that this complex was lipophilic and neutral. Biodistribution in mice showed that the complex accumulated in the brain with high uptake. The brain uptake (ID%/g) was 1.87, 1.21 and 0.85 and the brain/blood ratio was 0.75, 1.55 and 1.12 at 5, 30 and 60Â min post-injection, respectively. These results suggest that this complex could be a potential brain perfusion imaging agent.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
JunBo Zhang, Xiao Lin, Jialei Ren, Jing Liu, XueBin Wang,