| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1876739 | Applied Radiation and Isotopes | 2009 | 5 Pages |
Abstract
Changes in regional metabolic activities induced by middle cerebral artery occlusion (MCAO) can influence patient outcome. Our aim was to demonstrate in a rat model that 18F-FDG with positron emission tomography (PET) imaging is a quantitative, reproducible approach for identifying acute and sub-acute metabolic variations in infarct regions. We found that imaging with 18F-FDG/PET enabled detection and quantification of ischemia-induced metabolic deficits and provided a sensitive and reliable means of assessing cerebral ischemic lesions compared with conventional neurological scoring systems in rodents.
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Authors
Ying-Kai Fu, Chia-Jung Chang, Kuan-Yin Chen, Li-Chung Hwang, Kuo-Hung Wu, Kang-Wei Chang, Meei-Ling Jan, Chia-Chieh Chen, Chih-Hsien Chang,