Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876793 | Applied Radiation and Isotopes | 2009 | 6 Pages |
Abstract
A fully automated synthesis of the important 5HT1A receptor radioligand, [carbonyl-11C]WAY-100635 (I), was developed based on the optimized one-pot “wet” synthesis procedure. A modern automated apparatus was constructed from commercially available components and operated via LabView software. In average, (906±525) MBq (n=94) of (I) was obtained from 40 min bombardment at 50 μA beam current within 50 min synthesis time. The specific radioactivity (SA) at the time of injection was (50.5±29.3) GBq/μmol (n=94).
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Raisa N. Krasikova, Jan Andersson, Phong Truong, Sangram Nag, Evgeny V. Shchukin, Christer Halldin,