Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876800 | Applied Radiation and Isotopes | 2009 | 5 Pages |
Abstract
The 14N(ρ, α)11C reaction on N2–O2 or N2–H2 gaseous systems as targets in proton bombardment allows for the production of [11C]CO2 and [11C]CH4. We report the target production of [11C]CH4 and the gas phase iodination to produce [11C]CH3I with high specific radioactivity (SA). SA was calculated for four different radiopharmaceuticals produced in-house from both target produced [11C]CO2 and [11C]CH4. For [11C]raclopride we obtained an average SA of 3908 GBq/μmol (106 000 Ci/mmol) at the end of bombardment for the last 52 productions, which is a 32-fold increase compared to when using the in-house [11C]CO2 target.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Jan Andersson, Phong Truong, Christer Halldin,