Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1876900 | Applied Radiation and Isotopes | 2009 | 4 Pages |
The effect of administration mode of l-BPA and BSH on the biodistribution in the melanoma-bearing hamsters was investigated. In single intravenous (i.v.) administration, BSH (100 mg BSH/kg) showed no significant retention of 10B in all the tissues, including tumors, while long-term retention of 10B in the tumor, muscle and brain was observed with l-BPA (500 mg BPA/kg). The dose escalation of l-BPA and the simultaneous single administration of l-BPA and BSH were not so effective at increasing boron accumulation in tumor after bolus i.v. injection. The boron concentration in tumor was 41 μg B/g after single bolus i.v. injection even at the dose of 1000 mg BPA/kg. In contrast, two sequential bolus i.v. injections of l-BPA with the dose of 500 mg BPA/kg each was found to be effective at increasing 10B accumulation in the tumor; the maximum 10B concentration in the tumor reached 52 μg B/g at 3 h after the second i.v. injection.