Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877126 | Applied Radiation and Isotopes | 2008 | 9 Pages |
Abstract
A robust formulation was developed for [177Lu]Lu-AMBA (177Lu-DO3A-CH2CO-G-[4-aminobenzoyl]-QWAVGHLM-NH2), a Bombesin-like agonist with high affinity for Gastrin Releasing Peptide (GRP) receptors. During optimization of labeling, the effect of several radiostabilizers was evaluated; a combination of selenomethionine and ascorbic acid showed superiority over other tested radiostabilizers. The resulting two-vial formulation maintains a radiochemical purity (RCP) of >90% for at least 2 days at room temperature. The method of stabilization should be useful for other methionine-containing peptide radiopharmaceuticals in diagnostic and therapeutic applications.
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Authors
Jianqing Chen, Karen E. Linder, Aldo Cagnolini, Edmund Metcalfe, Natarajan Raju, Michael F. Tweedle, Rolf E. Swenson,