Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877314 | Applied Radiation and Isotopes | 2007 | 4 Pages |
Abstract
Electrochemical transfer of 18F− from enriched [18O]-water to pure acetonitrile was investigated to develop a simple and effective synthesis of 18F-radiopharmaceuticals. The transfer of 18F is composed of two steps: first step is electro-deposition on a graphite anode and the next step is electro-emission into pure acetonitrile by inversing the polarity of the electric tension. A sufficiently high fraction of the electro-emission, 73%, was achieved. The electrochemical transfer of 18F to aprotic polar solvents without any additives, such as phase transfer catalysis, will make the synthesis of diverse 18F-radiopharamceuticals simple and easy.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Fuminori Saito, Yasuyuki Nagashima, Akira Goto, Masaya Iwaki, Nobukazu Takahashi, Takashi Oka, Tomio Inoue, Toshio Hyodo,