Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877364 | Applied Radiation and Isotopes | 2007 | 5 Pages |
A novel fluorine-18 labeled amine fluorocyanoborane derivative was synthesized from the bromo-derivative precursor in 22% radiochemical yield. The [18F] labeling was accomplished by a semiautomatic method that is based on the synthesis of Ag18F from Ag2CO3 and H18F in a platinum dish followed by sonication of the bromo-precursor with Ag18F in dry benzene to produce [18F] labeled amine fluorocyanoborane which was used with no further purification. A total of 50 μCi of the [18F] labeled amine fluorocyanoborane was injected into normal, female Sprague–Dawley rats (250–300 g) via the tail vein and monitored by Positron emission tomography (PET)/CT to detect its biodistribution in the rat body. The images showed an uptake of this compound in the bones of rats.