Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877390 | Applied Radiation and Isotopes | 2007 | 6 Pages |
Abstract
A lipiodol solution of 188Re-4-hexadecyl-2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol (188Re-HDD/lipiodol) is in clinical study for liver cancer therapy. However, formulation of it is difficult due to highly active and unstable sulfhydryl groups. We produced new kits using diacetylated HDD (AHDD), in which sulfhydryl groups are protected. We found that AHDD kit can replace HDD kit due to an increased stability for formulation, the better radiolabeling efficiency (78%) and the equivalent biodistribution pattern in mice.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Yun-Sang Lee, Jae Min Jeong, Young Joo Kim, Young Soo Chang, Hak Jeong Lee, Miwon Son, Jung Woo Lee, Heung Sik Yoon, Won Jun Kang, Dong Soo Lee, June-Key Chung, Myung Chul Lee, Young-Ger Suh,