| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1877507 | Applied Radiation and Isotopes | 2015 | 5 Pages |
•The processing method is scalable for optimized purification of Ge-68 and Zn-65.•The purified Ge-68 meet DOE specifications and recoveries were >90%.•The processing methods were used to purify ~2.5 Ci of Ge-68 at BNL in 2012–2013.•New processing methods minimize potential of Ge-68/Ga-68 volatility.•The processing methods do not use toxic organic solvents and are FDA compliant.
Germanium-68 (Ge-68) is produced by proton irradiation of a gallium metal target, purified by organic extraction and used in a medical isotope generator to produce Gallium-68 PET imaging agents. The purpose of this work was to implement a production scale separation of Ge-68 and Zn-65 that does not use organic solvents and uses a limited number of columns. The current separation approach was modified to use AG1 resin and/or Sephadex© G25 with zinc spikes to purify Ge-68 with near quantitative recovery. The purified Ge-68 meets DOE specifications. Methods utilizing zinc spikes resulted in the purist Ge-68 produced at Brookhaven National Lab with no other impurities by ICP-OES. During process optimization approximately 2.5 Ci of Ge-68 was purified utilizing the different processing methods, and the material was sold to the Nuclear Medicine community between 2012–2013.
