| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1877571 | Applied Radiation and Isotopes | 2014 | 7 Pages |
•An efficient synthetic strategy (click chemistry) was used to improve the overall efficiency.•99mTc-HYNIC-T-FA showed a high tumor uptake but low no-target tissues uptakes.•Excellent tumor-to-kidney ratio was achieved by injecting PMX.•A kit formulation was developed to obtain the desired product without any purification.
The folate receptor is over expressed in a wide variety of human tumors. In this study, a novel 99mTc-labeled folate derivative (99mTc-HYNIC-T-FA) was synthesized as a potential FR-targeting imaging probe and its efficiency was evaluated. This 99mTc-complex could be obtained through practical manner and showed improved in vivo characteristics compared with other radiofolates. Thus, this novel 99mTc-HYNIC-T-FA compound could serve as a potential imaging agent for folate receptor positive tumors.
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