Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877749 | Applied Radiation and Isotopes | 2011 | 4 Pages |
Abstract
10B molecular compounds suitable for Boron Neutron Capture Therapy (BNCT) are tagged with a Gd(III) paramagnetic ion. The newly synthesized molecule, Gd-BPA, is investigated as contrast agent in Magnetic Resonance Imaging (MRI) with the final aim of mapping the boron distribution in tissues. Preliminary Nuclear Magnetic Resonance (NMR) measurements, which include 1H and 10B relaxometry in animal tissues, proton relaxivity of the paramagnetic Gd-BPA molecule in water and its absorption in tumoral living cells, are reported.
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Authors
M. Bonora, M. Corti, F. Borsa, S. Bortolussi, N. Protti, D. Santoro, S. Stella, S. Altieri, C. Zonta, A.M. Clerici, L. Cansolino, C. Ferrari, P. Dionigi, A. Porta, G. Zanoni, G. Vidari,