| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1877759 | Applied Radiation and Isotopes | 2011 | 4 Pages |
Abstract
The melanoma is a highly lethal skin tumor, with a high incidence. Boron Neutron Capture Therapy (BNCT) is a radiotherapy which combines Boron with thermal neutrons, constituting a binary system.B16F10 melanoma and L929 fibroblasts were treated with Boronophenylalanine and irradiated with thermal neutron flux. The electric potential of mitochondrial membrane, cyclin D1 and caspase-3 markers were analyzed.BNCT induced a cell death increase and cyclin D1 amount decreased only in B16F10 melanoma. Besides, there was not caspase-3 phosphorylation.
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Authors
F. Faião-Flores, P.R.P. Coelho, J. Arruda-Neto, Durvanei A. Maria,