Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877769 | Applied Radiation and Isotopes | 2011 | 4 Pages |
Abstract
Boron delivery characteristics of cis and trans isomers of a boronated unnatural amino acid, 1-amino-3-boronocyclopentanecarboxylic acid (ABCPC) were tested in the B16 mouse model for human melanoma. Both ABCPC isomers delivered comparable boron to B16 melanoma tumor cells as l-p-boronophenylalanine (BPA). Secondary ion mass spectrometry (SIMS) analysis revealed the presence of boron throughout the tumor from these compounds, and a near homogeneous distribution between the nucleus and cytoplasm of B16 cells grown in vitro. These encouraging observations support further studies of these new boron carriers in BNCT.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
George W. Kabalka, Aarif L. Shaikh, Rolf F. Barth, Tianyao Huo, Weilian Yang, Pamela M. Gordnier, Subhash Chandra,