Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877854 | Applied Radiation and Isotopes | 2011 | 6 Pages |
Abstract
We examined the production, separation, and characterization of 89Zr, including supplementation of a commercial Cyclone® 18/9 with a self-made Solid Target System (STS). Obtained [89Zr]Zr-oxalate was used for the labeling of anti-B cell antibodies with desferrioxamine-p-SCN as a bifunctional chelator. 89Zr-labeled antibodies were injected in DBA/1 mice to examine usability for detection of B cells in vivo. PET measurements showed binding of 89Zr-labeled anti-B cell antibodies in tissues with high frequencies of B cells, i.e. in spleen and lymph nodes.
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Authors
Martin Walther, Peter Gebhardt, Philipp Grosse-Gehling, Lydia Würbach, Ingo Irmler, Stephan Preusche, Muhammad Khalid, Thomas Opfermann, Thomas Kamradt, Jörg Steinbach, Hans-Peter Saluz,