Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1877916 | Applied Radiation and Isotopes | 2010 | 6 Pages |
Abstract
Sigma-2 receptors represent an endogenous marker for proliferation in solid tumors. The high affinity, high selectivity σ2 receptor ligand N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2-(2-fluoroethoxy)-5-iodo-3-methoxybenzamide (3) was separately radiolabeled with F-18 and I-125. The radiolabeling yield was 30% and 70% for [18F]3 and [125I]3, respectively. Studies of [125I]3 using murine 66 breast tumor membrane homogenates and evaluation of [18F]3 and [125I]3 in 66 tumor-bearing mice indicate that this ligand has potential as a PET or a SPECT probe for imaging σ2 receptors in breast cancer.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Zhude Tu, Jinbin Xu, Lynne A. Jones, Shihong Li, Dexing Zeng, Mei-Ping Kung, Hank F. Kung, Robert H. Mach,