| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1877930 | Applied Radiation and Isotopes | 2010 | 5 Pages |
Abstract
We present a novel analysis of membrane–protein expression in tissue sections based on semi-automatic real-time measurement using LigandTracer® technology. A commercial antiHER2 antibody developed for immunohistochemistry used in this setup was revealed to have sub-optimal interaction with tissue when analyzed as recommended for immunohistochemistry. We therefore think that real-time measurement of tissue, offering direct and quantitative membrane–protein interaction analysis, can lead to improved reproducibility and eliminate the subjective operator dependences that classical immunohistochemsitry suffers from.
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Authors
Lars Gedda, Hanna Björkelund, Karl Andersson,