Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878058 | Applied Radiation and Isotopes | 2010 | 6 Pages |
Abstract
Carbon-11-labeled tariquidar derivatives were first designed and synthesized as new PET agents for imaging of breast cancer resistance protein. The target tracers were prepared by O-[11C]methylation of their corresponding acid precursors using [11C]CH3OTf under basic conditions and isolated by a simplified solid-phase extraction (SPE) method in 50–60% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 15–20 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 111–185 GBq/μmol.
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Authors
Min Wang, David X. Zheng, Michael B. Luo, Mingzhang Gao, Kathy D. Miller, Gary D. Hutchins, Qi-Huang Zheng,