Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878092 | Applied Radiation and Isotopes | 2010 | 7 Pages |
Abstract
Carbon-11-labeled piperidine ring of N-[Ï-(6-methoxynaphthalen-1-yl)alkyl] derivatives were first designed and synthesized as new selective PET Ï1 receptor probes. The target tracers were prepared by O-[11C]methylation of their corresponding phenolic hydroxyl precursors using [11C]CH3OTf under basic conditions and isolated by a simplified SPE method in 40-50% radiochemical yields based on [11C]CO2 and decay corrected to EOB. The overall synthesis time from EOB was 15-20 min, the radiochemical purity was >99%, and the specific activity at EOS was 111-185 GBq/μmol.
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Authors
Mingzhang Gao, Min Wang, Gary D. Hutchins, Qi-Huang Zheng,