Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878168 | Applied Radiation and Isotopes | 2009 | 7 Pages |
Abstract
5-[18F]fluoro-2â²-deoxyuridine ([18F]FUdR) was synthesized using a robotic system as a proliferation probe for PET. [18F]FUdR was prepared via radiofluorodestannylation reaction from its organotin precursor. Biodistribution study and microPET imaging of [18F]FUdR in NG4TL4 sarcoma-bearing FVB/n mice were performed. The tumor-to-blood and tumor-to-muscle ratio increased steadily from 15 (1.81 and 3.42) to 120Â min (9.10 and 11.9) post injection. The dynamic microPET imaging demonstrates remarkable radioactivity retention in the tumor, which is consistent with the results of biodistribution study.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
C.W. Chang, Y.Y. Lin, C.J. Peng, M. Lin, R.S. Liu, S.J. Wang, W.J. Lin, H.E. Wang,