Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878176 | Applied Radiation and Isotopes | 2009 | 4 Pages |
Abstract
6-[124I]iodo-2-(4′-N,N-dimethylamino)-phenylimidazo[1,2-a]pyridine ([124I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [124I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.
Related Topics
Physical Sciences and Engineering
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Authors
K.W. Chang, C.C. Chen, S.Y. Lee, L.H. Shen, H.E. Wang,