Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878249 | Applied Radiation and Isotopes | 2008 | 8 Pages |
Abstract
In this paper, radionuclidic impurities generated during the bombardment of [18O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) were studied. In order to assess such impurities and the efficacy of purification methods through the different steps of the synthesis, samples of the target filters, purification columns, [18O]water recovered after the synthesis, and the final solution was collected and their activities measured and analyzed by means of a gamma-ray spectrometry system. The data demonstrated that purification methods adopted for the synthesis provide the [18F]FDG radionuclidically pure, as requested by the EU Pharmacopeia.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Mario Marengo, Filippo Lodi, Silvia Magi, Gianfranco Cicoria, Davide Pancaldi, Stefano Boschi,