| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1878283 | Applied Radiation and Isotopes | 2007 | 5 Pages |
Abstract
Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with 99mTc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of 99mTc(CO)3-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4–1% ID/g tumor uptake.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Kanchan Kothari, Sudhanand Prasad, Aruna Korde, Archana Mukherjee, Archana Mathur, Manu Jaggi, Meera Venkatesh, Ambikalmajan M.R. Pillai, Rama Mukherjee, Natesan Ramamoorthy,