| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1878355 | Applied Radiation and Isotopes | 2006 | 4 Pages |
Abstract
This work presents the preparation of radiolabelled cis-dichlorodiammineplatinum (II), CDDP*, sealed in a cadmium capsule. The irradiation of CDDP covered by cadmium, employing exposure times longer than 2 h, demonstrated good chemical purity and high specific activity. This finding allowed a better detection of in vivo CDDP* and suggests that it may be a good tool for studies of long-term biodistribution of pharmaceutical formulations containing this drug.
Related Topics
Physical Sciences and Engineering
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Radiation
Authors
Alexandre S. Leal, Álvaro D. Carvalho Júnior, Fabiana M. Abrantes, Maria Ângela de B.C. Menezes, Vany Ferraz, Tamara S. Cruz, Valbert N. Cardoso, Mônica C. de Oliveira,