Article ID Journal Published Year Pages File Type
1878356 Applied Radiation and Isotopes 2006 5 Pages PDF
Abstract

An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile–water gradient method on a Merck Purosphere RP-18 column was also developed.The highly purified precursor allowed the production of [11C]MP4A for PET studies of acethylcholine neurotransmission system. The tracer was produced with >98% radiochemical purity, with yields ranging 20–60% (decay-corrected) from EOB.

Related Topics
Physical Sciences and Engineering Physics and Astronomy Radiation
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