Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878356 | Applied Radiation and Isotopes | 2006 | 5 Pages |
Abstract
An improved synthesis of the precursor acetic acid-piperidine-4-yl ester by acetylation of 4-hydroxypiperidine hydrochloride in anhydrous chloroform was developed. A procedure for fast evaluation and characterization of products originated by acetylation of the 4-piperidinol using LC-APCI/MS with an acetonitrile–water gradient method on a Merck Purosphere RP-18 column was also developed.The highly purified precursor allowed the production of [11C]MP4A for PET studies of acethylcholine neurotransmission system. The tracer was produced with >98% radiochemical purity, with yields ranging 20–60% (decay-corrected) from EOB.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
A. Carpinelli, F. Magni, A. Cattaneo, M. Matarrese, E. Turolla, S. Todde, N. Bosso, M. Galli Kienle, F. Fazio,