Detailed balance in micro- and macrokinetics and micro-distinguishability of macro-processes

We develop a general framework for the discussion of detailed balance and analyse its microscopic background. We find that there should be two additions to the well-known T- or PT-invariance of the microscopic laws of motion:1.Equilibrium should not spontaneously break the relevant T- or PT-symmetry.2.The macroscopic processes should be microscopically distinguishable to guarantee persistence of detailed balance in the model reduction from micro- to macrokinetics.We briefly discuss examples of the violation of these rules and the corresponding violation of detailed balance.