Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878798 | Applied Radiation and Isotopes | 2013 | 5 Pages |
Abstract
•A fully automatized radiosynthesis of Flubatine under GMP conditions is reported.•Radiochemical yields of 30% in 40 min were achieved in more than 70 syntheses.•Specific activitiy of 3000 GBq/μmol and radiochemical purity of more than 97% were achieved.
A fully automatized radiosynthesis of (+)- and (−)-[18F]Flubatine ((+)- and (−)NCFHEB) by means of a commercially available synthesis module (TRACERlab FX FN) under GMP conditions is reported. Radiochemical yields of 30% within an overall synthesis time of 40 min were achieved in more than 70 individual syntheses. Specific activities were approximately 3000 GBq/μmol and radiochemical purity was determined to be at least 97%.
Keywords
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Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Marianne Patt, Andreas Schildan, Bernd Habermann, Steffen Fischer, Achim Hiller, Winnie Deuther-Conrad, Stephan Wilke, René Smits, Alexander Hoepping, Gudrun Wagenknecht, Jörg Steinbach, Peter Brust, Osama Sabri,