Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878868 | Applied Radiation and Isotopes | 2013 | 7 Pages |
Abstract
In this work, we used quantitative autoradiography to study the acute effect of cocaine, methamphetamine, and ketamine on the uptake of [18F]FDOPA in the striatum of rats. Drugs were treated 0.5 h before (pre-treated), and 1.5 h after (post-treated) [18F]FDOPA injections, rats were then sacrificed at 2 h post [18F]FDOPA injections to determine the striatum/frontal cortex binding ratios in the striatum. The ratios were lower in the post-treated groups than those of the pre-treated groups, suggesting a net effect of inhibition of trapping of the tracer. The order of uptake inhibition is: ketamine>methamphetamine>cocaine.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Chun-Kai Fang, Hong-Wen Chen, Wei-Hsun Wang, Ren-Shen Liu, Jeng-Jong Hwang,