Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1878880 | Applied Radiation and Isotopes | 2013 | 5 Pages |
Abstract
Clear cell sarcoma of tendons and aponeuroses (CCS) is a rare malignant tumor with no effective treatment. This study demonstrates the efficacy of BNCT with the use of human CCS-bearing nude mice. Groups A and C were administered saline, and groups B and D were injected with p-borono-l-phenylalanine-fructose complex. Groups C and D were then irradiated with thermal neutrons. The tumors in only group D disappeared, demonstrating that BNCT is a potentially new option for the treatment of human CCS.
► Human clear cell sarcoma (CCS)-bearing nude mice were used in this study. ► The human CCS in the nude mice disappeared after BNCT. ► The efficacy of BNCT for human CCS is demonstrated here for the first time.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Hiroshi Moritake, Tohru Sugimoto, Toshiko Sakuma, Toshihiro Akisue, Shinji Kawabata, Mitsunori Kirihata, Minoru Suzuki, Yoshinori Sakurai, Koji Ono, Yoshinobu Fukumori, Masahiro Kurosaka,