Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879002 | Applied Radiation and Isotopes | 2012 | 6 Pages |
Abstract
Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [123I]ADAM ([123I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters.We assessed the toxicity of [123I]ADAM (18.5 MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs.In conclusion, [123I]ADAM was not toxic in an animal pregnancy model.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
K.W. Chang, M.C. Lin, S.Y. Lee, H.Y. Chen, C.C. Chen, Y.K. Fu,