Predicting the yield of 177Lu radionuclide produced by the cyclic irradiation technique

The feasibility study on the production of 177Lu radioisotope using a low power research reactor has been conducted. A reliable method for predicting the yield of 177Lu produced using the cyclic activation technique based on the Westcott formalism has been established. A specific activity of 243.24 mCi/g was obtained when a 176Lu2O3 of natural abundance was irradiated for 4 h and decayed for 20 h for four cycles at GHARR-1 with a neutron flux of 5.0×1011 ncm−2 s−1.