Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879375 | Applied Radiation and Isotopes | 2010 | 4 Pages |
Abstract
N-[11C]-methyl-hydroxyfasudil was synthesized as a new potential radiotracer for rho-kinases (ROCKs) via a two-step one-pot radiosynthesis. The first step was the methylation of the precursor N-Boc-hydroxyfasudil-sodium salt/benzo-15-crown-5 complex with [11C]methyl iodide. The second step involved deprotection of the tert-butoxycarbonyl protecting group. The radiochemical and chemical purities of N-[11C]-methyl-hydroxyfasudil were >95% and specific radioactivity was 1565–2565 mCi/μmol at the end of the synthesis.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Ana C. Valdivia, Samantha Mason, Jeffrey Collins, Kenneth R. Buckley, Paul Coletta, Rob S. Beanlands, Jean N. DaSilva,