Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879376 | Applied Radiation and Isotopes | 2010 | 5 Pages |
Abstract
Click chemistry is a useful approach for the preparation of novel radiopharmaceuticals. In this study, we evaluated 4-[18F]fluoro-1-butyne as a radiolabeled synthon for click chemistry with azido compounds. Our results showed that nucleophilic substitution of 4-tosyloxy-1-butyne with K[18F]F produces vinyl acetylene as well as 4-[18F]fluoro-1-butyne, while the same reaction using 5-tosyloxy-1-pentyne gives exclusively 5-[18F]fluoro-1-pentyne. Thus, ω-[18F]fluoro-1-alkynes with chain lengths longer than four carbons may be better radiolabeled synthons for use in click chemistry.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Dong Hyun Kim, Yearn Seong Choe, Byung-Tae Kim,