Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879377 | Applied Radiation and Isotopes | 2010 | 6 Pages |
Abstract
We have developed a radiolabeling strategy for synthetic polymers based on the formation of azo dye usable for both covalent and chelating labeling modalities under mild conditions. Poly[N-(2-hydroxypropyl)methacrylamide] and poly(N-isopropyl acrylamide) were used as model polymers. N-methacryloyl tyrosinamide was introduced into the polymers and the phenolic moiety was then reacted with diazotized chelator precursors. The conjugates were radiolabeled with both the covalently bound (iodine-125) and chelated (indium-111) radionuclides in high yields and sufficient in vitro stability of the labels was proven.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Martin Hruby, Jan Kucka, Michaela Novakova, Hana Mackova, Miroslav Vetrik,