Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879406 | Applied Radiation and Isotopes | 2009 | 4 Pages |
Abstract
Three new hydroxamamide derivatives with different lipophilicity, Nâ²-hydroxy-N-methyl-3-(4-nitro-1H-imidazol-1-yl)propanamidine, N-butyl-Nâ²-hydroxy-3-(4-nitro-1H-imidazol-1-yl)propanamidine, and Nâ²-hydroxy-3-(4-nitro-1H-imidazol-1-yl)-N-octadecylpropanamidine were easily synthesized and labeled with technetium-99m as markers for hypoxic cells. The results of in vitro experiment indicate that the accumulation of three 99mTc-complexes steadily increases with time in hypoxic cells, but fluctuates with time and has no fixed trend in aerobic cells; the complex with higher lipophilicity shows more uptake in cells; and the effect of lipophilicity of the 99mTc-complexes on the hypoxic/aerobic difference can be neglected.
Keywords
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Taiwei Chu, Hong Xu, Zhi Yang, Xiangyun Wang,