Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879407 | Applied Radiation and Isotopes | 2009 | 4 Pages |
Abstract
This work reports the synthesis, radiolabeling and preliminary in vitro evaluation of [131I]-5-iodo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-yl)-ethyl]-2-methoxy-benzamide. The tributylstannylprecursor was synthesized with a yield of 38%. Radiolabeling was performed using an electrophilic iododestannylation. Tracer yield was 94%, radiochemical purity was >95%. The tracer showed high uptake in MCF-7 breast cancer cell line and therefore will be evaluated further.
Related Topics
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Authors
Yu Ping Xu, Min Yang, Dong Hui Pan,