| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1879447 | Applied Radiation and Isotopes | 2009 | 7 Pages |
Abstract
This work analysed the influence of the chelating group and radioligand on somatostatin analogues in vivo and in vitro properties. The presence of DOTA in the radioiodinated peptide produced a labeled analogue with similar blood kinetics and biodistribution to 177Lu-DOTATATE and with lower abdominal uptake than 131I-TATE. In addition, 131I-DOTATATE showed significative tumour uptake, despite not so persistent after 24 h. 131I-DOTATATE can represent a cost-effective alternative to lutetium labeled peptide for neuroendocrine tumours therapy.
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Authors
E.B. de Araújo, J.S. Caldeira Filho, L.T. Nagamati, E. Muramoto, M.T. Colturato, R.M. Couto, P.B. Pujatti, J. Mengatti, C.P.G. Silva,