Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879500 | Applied Radiation and Isotopes | 2008 | 4 Pages |
Abstract
No-carrier-added astatine radionuclides produced in the 7Li-irradiated lead matrix were separated from bulk lead nitrate target by complexing At with insulin, followed by dialysis. The method offers simultaneous separation of At from lead as well as its complexation with insulin. The At-insulin complex might be a potential radiopharmaceutical in the treatment of hepatocellular carcinoma. The stability of At-insulin complex was checked by dialysis against deionized water and Ringer lactate (RL) solution. It has been found that the half-life of At-insulin complex is about â¼12Â h, when dialyzed against deionized water and is only 6Â h, when dialyzed against RL solution having the same composition as blood serum. The 6Â h half-life of this Insulin-At complex is perfect for killing cancer cells from external cell surfaces as the half-life of internalization of insulin molecule inside the cell is 7-12Â h.
Related Topics
Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Susanta Lahiri, Kamalika Roy, Souvik Sen,