| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1879686 | Applied Radiation and Isotopes | 2007 | 7 Pages |
Abstract
An automated, one-pot radio-synthesis module for the routine preparation of 1-[11C]acetoacetic acid has been developed. The enolate anion of acetone was reacted with [11C]CO2 in tetrahydrofuran (THF), followed by hydrolysis and purification by ion-exchange chromatography. The total synthesis time was 18 min and radiochemical yield was 34% after decay correction. HPLC analysis showed ⩽3% impurities while residual THF (⩽200 ppm) and ethanol (⩽500 ppm) were well under the tolerable limits for human studies.
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Authors
Sébastien Tremblay, René Ouellet, Serge Rodrigue, Réjean Langlois, François Bénard, Stephen C. Cunnane,