Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1879739 | Applied Radiation and Isotopes | 2007 | 6 Pages |
Abstract
Bis-ligand cobalt(II) complexes of four 3-hydroxy-4-pyridinone ligands with pendant carbohydrates were synthesized and examined for their potential as radiopharmaceuticals. Non-radioactive complexes were prepared on the macroscopic scale and characterized by elemental analysis, mass spectrometry, IR and UV/visible spectroscopy. Facile radiolabeling produced the 55Co complexes in high radiochemical yields (>95%). Identification of the radiolabeled compounds was accomplished by HPLC comparison with the corresponding non-radioactive complexes.
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Physical Sciences and Engineering
Physics and Astronomy
Radiation
Authors
Cara L. Ferreira, Suzanne Lapi, Jennifer Steele, David E. Green, Thomas J. Ruth, Michael J. Adam, Chris Orvig,