Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1894066 | Chaos, Solitons & Fractals | 2007 | 8 Pages |
We biologically describe the phenomenon of the evasion of tumors from immune surveillance where tumor cells, initially constrained to exist in a microscopic steady state (MISS) elaborate strategies to evade from the immune control and to reach a macroscopic steady state (MASS). We, then, describe “evasion” as a long term loss of equilibrium in a framework of prey–predator-like models with adiabatic varying parameters, whose changes reflect the evolutionary adaptation of the tumor in a “hostile” environment by means of the elaboration of new strategies of survival. Similarities and differences between the present work and the interesting seminal paper [Kuznetsov VA, Knott GD. Modeling tumor regrowth and immunotherapy. Math Comput Model 2001;33:1275–87] are discussed. We also propose and study a model of clonal resistance to the immune control with slowly varying adaptive mutation parameter.