Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1899091 | Physica D: Nonlinear Phenomena | 2006 | 7 Pages |
Abstract
In this paper, we consider the effect of viral diversity on the human immune system with frequency dependent rate of proliferation of CTLs (cytotoxic T-lymphocytes) and rate of elimination of infected cells by CTLs. We show that the interior equilibrium of our model can become unstable without viral diversity and we observe stable periodic orbits. Furthermore, our mathematical models suggest that viral diversity produces strange attractors.
Related Topics
Physical Sciences and Engineering
Mathematics
Applied Mathematics
Authors
Shingo Iwami, Shinji Nakaoka, Yasuhiro Takeuchi,