| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1902277 | Ageing Research Reviews | 2012 | 9 Pages |
Gene expression patterns vary dramatically in a tissue-specific and age-dependent manner. RNA-binding proteins that regulate mRNA turnover and/or translation (TTR-RBPs) critically affect the subsets of expressed proteins. Although many proteins implicated in age-related processes are encoded by mRNAs that are targets of TTR-RBPs, very little is known regarding the tissue- and age-dependent expression of TTR-RBPs in humans. Recent analysis of TTR-RBPs expression using human tissue microarray has provided us interesting insight into their possibly physiologic roles as a function of age. This analysis has also revealed striking discrepancies between the levels of TTR-RBPs in senescent human diploid fibroblasts (HDFs), widely used as an in vitro model of aging, and the levels of TTR-RBPs in tissues from individuals of advancing age. In this article, we will review our knowledge of human TTR-RBP expression in different tissues as a function of age.
► Many age-related proteins are encoded by mRNAs that are targets of TTR-RBPs. ► There are discordances between TTR-RBPs levels in senescent fibroblasts and in tissues from elderly donors. ► The systematic analysis of TTR-RBPs provides a framework to study the possible involvement of TTR-RBPs in age-related processes.
