Circadian clocks and antiaging: Do non-aging microalgae like Euglena reveal anything?

Microalgae that divide symmetrically in all aspects do not age. While the evolutionary reason for this is obvious, little attention has been paid to the mechanistic explanations. A great deal of study involving many research fields would be needed to explain the mechanisms if we suppose that the immortality results from a lifelong sufficiency of defense from stress or from an essential part of counteracting age-accompanied damage accumulation. Additionally, little is known about the relationships between homeostasis and circadian clocks in antiaging, although each of these has been studied separately. Here, we present a conceptual generalization of those relationships, as suggested by evidence from non-aging microalgae, mainly Euglena. The circadian gating of mitosis and circadian temporal coordination may respectively reduce radiation- and disharmony-induced stress in which homeostasis cannot be involved, whereas circadian resistance rhythms may greatly help homeostatic defense from radiation- and metabolism-induced stress. We also briefly sketch mammalian aging research to compare the current status of knowledge with that of algal antiaging.