Determination of a critical size calvarial defect in senile osteoporotic mice model based on in vivo micro-computed tomography and histological evaluation

Defects of 2 mm or larger in the cranium was critical-size or nonhealing defects in both SAMP6 and SAMR1. The differential findings on micro-CT and histomorphometry for the calvarial defect sites between SAMP6 and SAMR1 may imply different regenerative abilities of intramembranous ossification in these two strains.