| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1902785 | Archives of Gerontology and Geriatrics | 2015 | 4 Pages |
•The MoCA associates with severity of GCA.•MoCA scores may be used as reliable estimates of structural brain damage.•MoCA cut-offs for cognitive impairment should be lower in underserved populations.
Background/objectiveIncreasing numbers of individuals with cognitive impairment are posing economic threads to the developing world. Proper assessment of this condition may be complicated by illiteracy and cross-cultural factors. We conducted a population-based study in elders living in rural Ecuador to evaluate whether the MoCA associated with structural brain damage in less-educated populations.MethodsAtahualpa residents aged ≥60 years were identified during a door-to-door survey and invited to undergo MRI for grading GCA. Using a multivariate generalized linear model, we evaluated whether MoCA scores correlates with GCA, after adjusting for demographics, education, cardiovascular health (CVH) status, depression and edentulism.ResultsOut of 311 eligible persons, 241 (78%) were enrolled. Mean age was 69.2 ± 7.5 years, 141 (59%) were women, 199 (83%) had primary school education, 175 (73%) had poor CVH status, 30 (12%) had symptoms of depression and 104 (43%) had edentulism. Average MoCA scores were 18.5 ± 4.7 points. GCA was mild in 108, moderate in 95, and severe in 26 persons. Total and most domain-specific MoCA scores were significantly worse in persons with moderate to severe GCA. In the multivariate model, mean MoCA score was associated with GCA severity (β = 2.38, SE = 1.07, p = 0.027).ConclusionsMoCA scores associate with severity of GCA after adjusting for potential confounders, and may be used as reliable estimates of structural brain damage. However, a lower cut-off than that recommended for developed countries, would be better for recognizing cognitive impairment in less educated populations.
