| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1904992 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2012 | 12 Pages |
Abstract
⺠One of the mechanisms causing SCA1 neurodegeneration could involve membrane destabilization. ⺠We analyzed the interaction between normal or expanded ataxin 1 and lipid membranes. ⺠Morphological analyses revealed nuclear membrane damage of cells expressing toxic ataxin 1. ⺠Atomic force microscopy and electrophysiology showed increased membrane fragility and permeability. ⺠We suggest that expanded ataxin 1 induces unregulated ionic pathways in the nuclear membrane.
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Authors
Lisa Mapelli, Claudio Canale, Daniela Pesci, Stefania Averaimo, Fabiana Guizzardi, Valentina Fortunati, Laura Falasca, Mauro Piacentini, Alessandra Gliozzi, Annalisa Relini, Michele Mazzanti, Carla Jodice,