Relevance of mast cell–nerve interactions in intestinal nociception

Cross-talk between the immune- and nervous-system is considered an important biological process in health and disease. Because mast cells are often strategically placed between nerves and surrounding (immune)-cells they may function as important intermediate cells. This review summarizes the current knowledge on bidirectional interaction between mast cells and nerves and its possible relevance in (inflammation-induced) increased nociception. Our main focus is on mast cell mediators involved in sensitization of TRP channels, thereby contributing to nociception, as well as neuron-released neuropeptides and their effects on mast cell activation. Furthermore we discuss mechanisms involved in physical mast cell–nerve interactions. This article is part of a Special Issue entitled: Mast cells in inflammation.

Research highlights► Mast cell-neuron communication can have major implications in various diseases. ► Mast cell mediators can sensitize neuronal receptors contributing to pain perception. ► Neuropeptides released by activated neurons can modulate mast cell activation. ► This review summarizes current knowledge on mast cell-neuron communication.